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NEW QUESTION: 1
Which of the following statements is true regarding Drug-receptor bonds?
A. Electrostatic bonds are stronger than covalent bonds
B. Hydrophobic bonds are weak bonds and they are important in the interactions of highly water soluble drugs with the lipids of cell membranes
C. Covalent bonds of drugs with receptors are strong and mostly reversible
D. Covalent bonding is much more common than electrostatic bonding in drug-receptor interactions
E. Bond formation of between the acetyl group of aspirin and cyclo-oxygenase enzyme is a covalent bond
Answer: E
Explanation:
Explanation
Drugs mainly interact with the receptors by means of chemical forces or bonds. There are three major types of drug receptor bonds: - Covalent - Electrostatic - Hydrophobic Covalent bonds are very strong bonds and in most of the cases they are irreversible under biologic conditions. For example, the covalent bond between the acetyl group of aspirin and cyclo-oxygenase enzyme (target enzyme present on the platelets) does not breaks easily. The platelet aggregation effect of aspirin lasts long after free acetyl-salicylic acid has disappeared from the blood (about 15 minutes) and it is reversed only by the synthesis of new cyclo-oxygenase enzyme in new platelets which takes a long time. Hence the effect of aspirin is seen after the drug is stopped. Among the drug receptor interactions, electrostatic bond is much more commonly found than covalent bond. The electrostatic bonds vary from relatively strong linkages between permanently charged ionic molecules to weaker hydrogen bonds and very weak induced dipole interactions such as van der Waals force. The electrostatic bonds are weaker than covalent bonds. Hydrophobic bonds are usually very weak bonds and probably important in the interactions of highly lipid soluble drugs with the lipids of cell membranes and perhaps in the interactions of the drugs with the internal walls of receptor "pockets".
NEW QUESTION: 2
単一のポートが障害BPDUを受信したときにerr-disabled状態になるように設定するには、どのコマンドを入力する必要がありますか
A. spanning-tree guard root
B. spanning-tree portfast bpduguard
C. spanning-tree portfast bpdufilter
D. spanning-tree portfast default
Answer: B
NEW QUESTION: 3
The nurse would be sure to instruct a client on the signs and symptoms of an eye infection and hemorrhage. These signs and symptoms would include:
A. Feeling of eye pressure and headache
B. Eye discharge and hemoptysis
C. Blurred vision and dizziness
D. Eye pain and itching
Answer: D
Explanation:
Explanation/Reference:
Explanation:
(A) Although blurred vision may occur, dizziness would not be associated with an infection or hemorrhage.
(B) Eye pain is a symptom of hemorrhage within the eye, and itching is associated with infection. (C) Nausea and headache would not be usual symptoms of eye hemorrhage or infection. (D) Some eye discharge might be anticipated if an infection is present; hemoptysis would not.
NEW QUESTION: 4
CORRECT TEXT
Please specify the top directory containing the configuration files for the CUPS printing system. (Provide the full path to the directory)
Answer:
Explanation:
/etc/cups, /etc/cups/